Mazatlán are un aeroport international - General Rafael Buelna International Airport, cunoscut sub numele de Aeroportul International Mazatlán. Acesta primeste calatorii internationale de la: Dallas / Ft. Worth, Los Angeles, San Francisco, Portland, Houston, South Shore Harbor, Salt Lake City, Phoenix, Denver, Minneapolis, Calgary, Edmonton, Regina, Saskatoon, Toronto-Pearson, Vancouver si Winnipeg.

Puteti ajunge la Mazatlán si alegand un zbor catre Mexico City, de unde va veti putea imbarca intr-un alt avion catre destinatia finala.